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Updated: Nov 4, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Can diallyl trisulfide, a dietary garlic-derived compound, activate ferroptosis to overcome therapy resistance in
Angela Lincy Prem Antony Samy1, Dhruvi Shah1, Preksha Shahagadkar1
1Department of Biomedical Sciences, 14681University of Illinois College of Medicine, Rockford, IL, USA.
Background:
Therapy resistance is the underlying reason for poor outcome in prostate cancer (PCa) patients. Diallyl trisulfide (DATS) is an organosulfur compound present in garlic. DATS has been shown to target PCa cells by induction of apoptosis, increase in the production of reactive oxygen species, degradation of ferritin protein and increase in the labile iron (Fe) pool.
Aim:
We hypothesize that DATS could induce ferroptosis, an Fe-dependent, unique non-apoptotic form of regulated cell death to eliminate therapy resistance encountered by PCa patients.
Methods:
In vitro and in vivo studies should be performed to test the hypothesis.
Results:
As per the hypothesis, DATS would eliminate apoptotic resistance via inducing ferroptosis.
Conclusion:
Since apoptosis resistance has been reported to be the underlying mechanism of therapy resistance in PCa, DATS could be used to effectively target PCa cells by overcoming apoptosis resistance and inducing ferroptosis-mediated cell death of PCa cells.
Insights
Diallyl trisulfide (DATS) may overcome therapy resistance in prostate cancer (PCa) by inducing ferroptosis, a unique cell death pathway. This research explores DATS as a novel therapeutic strategy for PCa patients.
Area of Science:
- Oncology
- Biochemistry
- Pharmacology
Background:
- Therapy resistance significantly impacts outcomes for prostate cancer (PCa) patients.
- Diallyl trisulfide (DATS), a garlic-derived organosulfur compound, exhibits anti-cancer properties.
- DATS targets PCa cells through apoptosis induction, reactive oxygen species generation, ferritin degradation, and increased labile iron.
Purpose of the Study:
- To investigate the potential of DATS in inducing ferroptosis, an iron-dependent cell death, to combat therapy resistance in PCa.
- To test the hypothesis that DATS can overcome apoptotic resistance in PCa cells.
Main Methods:
- In vitro studies to assess DATS effects on PCa cells.
- In vivo studies to evaluate DATS efficacy in a relevant model.
Main Results:
- The study hypothesizes that DATS will induce ferroptosis, thereby overcoming apoptotic resistance.
- DATS is expected to eliminate therapy resistance by promoting ferroptosis-mediated cell death.
Conclusions:
- DATS shows promise in targeting PCa cells by overcoming apoptosis resistance.
- Inducing ferroptosis with DATS represents a potential strategy to treat therapy-resistant prostate cancer.
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