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Hyperlactatemia associated with diabetic ketoacidosis in pediatric intensive care unit

Jingwei Liu1, Haibo Yan1, Yumei Li2

  • 1Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Xin Min Street, 130021, Changchun, China.

BMC Endocrine Disorders
|May 28, 2021
PubMed

Insights

Children with diabetic ketoacidosis (DKA) and hyperlactatemia may show higher heart rates and diastolic blood pressure. These factors, along with disease severity, are linked to hyperlactatemia in pediatric DKA.

Area of Science:

  • Pediatric Endocrinology
  • Critical Care Medicine
  • Biochemistry

Background:

  • Diabetic ketoacidosis (DKA) in children is frequently associated with elevated lactate levels.
  • Hyperlactatemia is a common finding in pediatric DKA, necessitating investigation into its clinical correlates.

Purpose of the Study:

  • To identify clinical variables associated with the development of hyperlactatemia in pediatric patients with diabetic ketoacidosis.
  • To explore the relationship between lactate levels and clinical outcomes in pediatric DKA.

Main Methods:

  • A retrospective descriptive study was conducted at a single pediatric intensive care unit.
  • 107 pediatric patients diagnosed with diabetic ketoacidosis were analyzed.

Main Results:

  • Hyperlactatemia developed in 61 out of 107 patients.
  • Multivariate logistic regression identified elevated heart rate, diastolic blood pressure, and disease severity stage as independent predictors of hyperlactatemia in DKA.
  • Lactate levels did not show a significant association with hospital stay duration or time to DKA resolution.

Conclusions:

  • Pediatric DKA patients with higher severity, elevated heart rate, and increased diastolic blood pressure are more susceptible to hyperlactatemia.
  • Hyperlactatemia in pediatric DKA is not significantly correlated with prolonged hospital stay or delayed DKA resolution.
Abstract

Keywords:
Diabetes mellitusDiabetic ketoacidosisLactate

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