Anticoagulation and antibacterial properties of heparinized nanosilver with different morphologies

Synthesis and characterization of nanoparticles with different morphologies coupled to minimal chemical interventions for sustainable applications is one of the contemporary topics in the field of nanotechnology. In the current study, heparinized silver nanoparticles were synthesized using a chemical reduction method. Different concentrations of heparin were used to investigate its role in the stability and morphological properties of silver nanoparticles. Interestingly, it has been observed that the concentration of the stabilizing agent heparin plays a pivotal role in dictating the size and shape of the nanosilver. As visualized under a transmission electron microscope, nanosilver with different morphological states such as triangles, truncated triangles, hexagon, and spheres has been experimentally trapped. Such modular property of heparin coated nanosilver has also exhibited substantial differences in their anticoagulation and antimicrobial activities.