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Related Concept Videos

Ultrasonography01:17

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called a...

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Related Experiment Video

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MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model
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How to Perform Intra-Operative Contrast-Enhanced Ultrasound of the Brain-A WFUMB Position Paper.

Francesco Prada1, Ignazio G Vetrano2, Antonio G Gennari3

  • 1Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; Department of Neurological Surgery, University of Virginia Health Science Center, Charlottesville, VA, USA; Focused Ultrasound Foundation, Charlottesville, VA, USA.

Ultrasound in Medicine & Biology
|May 28, 2021
PubMed
Summary

Intra-operative contrast-enhanced ultrasound (ioCEUS) offers advanced brain imaging for neurosurgery, improving tumor definition and vascular mapping beyond traditional B-mode ultrasound. This guide details ioCEUS procedures and technical aspects for enhanced surgical precision.

Keywords:
Brain tumorsCEUSCentral nervous systemContrast-enhanced ultrasoundIntraoperative ultrasoundsNeurosurgeryNeurovascular diseases

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Area of Science:

  • Neurosurgery
  • Medical Imaging
  • Ultrasound Technology

Background:

  • Intra-operative ultrasound (ioUS) is crucial in neurosurgery.
  • B-mode ultrasound has limitations in detailed tissue characterization.
  • Intra-operative contrast-enhanced ultrasound (ioCEUS) is an emerging advanced imaging tool.

Purpose of the Study:

  • To present a standardized protocol for performing ioCEUS of the brain.
  • To highlight the specific applications of ioCEUS in neurosurgical procedures.
  • To offer practical guidance on contrast agent selection and technical parameter optimization.

Main Methods:

  • Detailed step-by-step procedure for brain ioCEUS acquisition.
  • Discussion of neurosurgical applications, including tumor boundary definition and vascular mapping.
  • Review of ultrasound contrast agents and key technical parameters (e.g., frequency, gain, depth).

Main Results:

  • ioCEUS effectively defines tumor margins and differentiates tumor from surrounding tissue.
  • ioCEUS accurately identifies lesion vascular supply and maps critical neurovascular structures.
  • The proposed protocol facilitates reproducible and reliable ioCEUS imaging in neurosurgery.

Conclusions:

  • ioCEUS is a valuable adjunct to B-mode ultrasound in neurosurgery.
  • ioCEUS enhances surgical precision by providing superior visualization of tumor vascularity and boundaries.
  • Standardized protocols and understanding of technical parameters are essential for optimal ioCEUS performance.