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Updated: Nov 4, 2025

Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry
Published on: September 6, 2016
Mesoscopic and multiscale modelling in materials
Jacob Fish1, Gregory J Wagner2, Sinan Keten2
1Columbia University, New York, NY, USA. fishj@columbia.edu.
Abstract:
The concept of multiscale modelling has emerged over the last few decades to describe procedures that seek to simulate continuum-scale behaviour using information gleaned from computational models of finer scales in the system, rather than resorting to empirical constitutive models. A large number of such methods have been developed, taking a range of approaches to bridging across multiple length and time scales. Here we introduce some of the key concepts of multiscale modelling and present a sampling of methods from across several categories of models, including techniques developed in recent years that integrate new fields such as machine learning and material design.
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