Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

105
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
105
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

2.6K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.6K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

109
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
109
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

78.4K
Overview
78.4K
Tissue Transplantation01:24

Tissue Transplantation

668
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
668
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

122
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
122

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accelerating Mechanistic Biomarker Discovery in Antibody-mediated Rejection Through Spatial Transcriptomics.

Transplantation·2026
Same author

Clinical Utility and Impact of Phosphatidylethanol (PEth) Testing in Patients Pursuing Kidney Transplantation.

Journal of the Academy of Consultation-Liaison Psychiatry·2026
Same author

Abdominal Arterial Calcification as an Imaging Biomarker of Mortality in Kidney Transplant Waitlist Patients.

Nephrology (Carlton, Vic.)·2026
Same author

Clazakizumab for chronic active antibody-mediated rejection: Lessons from the IMAGINE trial and the path forward.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Donor Mentoring in Private Kidney Paired Donation Programs: The Need for Transparency and Accountability.

Transplantation·2026
Same author

The Banff 2024 Kidney Meeting Report: Rejection as a spectrum of phenotypes and focus on differential diagnostic reasoning.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026

Related Experiment Video

Updated: Nov 4, 2025

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.6K

Current Approaches to Desensitization in Solid Organ Transplantation.

Carrie Schinstock1, Anat Tambur2, Mark Stegall1

  • 1William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN, United States.

Frontiers in Immunology
|May 28, 2021
PubMed
Summary

This review guides desensitization decisions for kidney transplantation, considering HLA antibody incompatible transplant outcomes. It also discusses novel therapeutics and future research directions for solid organ transplantation.

Keywords:
antibody mediated rejectioncrossmatchdesensitizationdonor specific antibody (DSA)kidney paired donationkidney transplantationsensitizationsingle antigen bead assays (SAB)

More Related Videos

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

20.6K
Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
06:48

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

13.5K

Related Experiment Videos

Last Updated: Nov 4, 2025

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.6K
Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

20.6K
Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
06:48

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

13.5K

Area of Science:

  • Transplantation immunology
  • Solid organ transplantation
  • Immunosuppression

Background:

  • Significant advancements in HLA antibody detection and solid organ transplant outcomes have occurred.
  • Kidney paired donation programs and updated deceased donor allocation policies are now widespread.
  • Emerging therapeutic options show promise in reducing HLA antibody levels.

Purpose of the Study:

  • To provide guidance on considering desensitization for kidney transplantation.
  • To review outcomes of HLA antibody incompatible kidney transplantation.
  • To discuss novel therapeutics, desensitization endpoints, and future research strategies.

Main Methods:

  • Literature review and synthesis of current knowledge on HLA antibody detection and desensitization protocols.
  • Analysis of outcomes data from HLA antibody incompatible solid organ transplantation.
  • Discussion of emerging therapeutic agents and their potential impact.

Main Results:

  • HLA antibody detection and management have evolved significantly over the past 50 years.
  • Desensitization protocols are increasingly considered for HLA antibody incompatible kidney transplantation.
  • Novel therapeutics offer potential for improved outcomes in sensitized transplant candidates.

Conclusions:

  • Careful consideration of desensitization is crucial for HLA antibody incompatible kidney transplantation.
  • The principles discussed for kidney transplantation are applicable to other solid organ transplants.
  • Further research into novel therapeutics and desensitization endpoints is warranted.