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Updated: Nov 4, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
Sophia A Ederaine1, Johanny Lopez Dominguez1, Jamison A Harvey2
1Mayo Clinic Alix School of Medicine, Scottsdale, AZ 85259, USA.
Aim:
This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control.
Materials & Methods:
Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007-2017). Overall survival and recurrence-free survival were estimated using the Kaplan-Meier method. Hemoglobin A1c (HbA1c) and glucose level during the year following cancer diagnosis were compared using mixed models.
Results:
HbA1c decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004).
Conclusion:
The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control.
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