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Updated: Nov 4, 2025
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis
Chihiro Kiyoshima1, Naoto Shirasu2,3, Daichi Urushiyama1
1Department of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan.
Background:
This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis.
Materials & Methods:
Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc's criteria.
Results:
The expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for severe chorioamnionitis, and was linked to maternal and fetal inflammation.
Conclusion:
miR-4535 and miR-1915-5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis.
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