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Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
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Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?
Giuseppa Graceffa1, Gregorio Scerrino2, Gabriella Militello2
1Department of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Future Science OA
|May 28, 2021
Summary
Thyroid autoimmunity, particularly antithyroid peroxidase antibodies, significantly elevates breast cancer risk. Other thyroid diseases, including thyroid cancer, did not show this association, indicating autoimmunity
Area of Science:
- Endocrinology
- Oncology
- Immunology
Background:
- Investigating the link between thyroid diseases and subsequent breast cancer development.
- Understanding the specific role of thyroid autoimmunity in this association.
Purpose of the Study:
- To determine if specific thyroid diseases increase the risk of later breast cancer.
- To evaluate the contribution of thyroid autoimmunity to breast cancer development.
Main Methods:
- Retrospective observational study comparing 410 females with thyroid surgery and breast cancer to 524 females with thyroid surgery only.
- Analysis included pathological thyroid findings, thyroid hormones, thyroid autoimmunity markers, and breast cancer type.
Main Results:
- Thyroid autoimmunity, especially antithyroid peroxidase antibodies, significantly increased breast cancer risk (p < 0.01).
- No significant association was found between other thyroid diseases (including thyroid cancer) and breast cancer risk.
- No specific breast cancer variant was predominant; only thyroid autoimmunity showed a clear association.
Conclusions:
- Thyroid autoimmunity is a significant risk factor for developing breast cancer.
- Other thyroid diseases, such as thyroid cancer, are not associated with an increased risk of breast cancer.
- Further research is required to elucidate the precise mechanisms involving different antithyroid antibodies.
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