Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Evaluation on ceftriaxone administered intravenously in neonates].

S Nakazawa1, H Satoh, A Narita

  • 1Department of Pediatrics, Tokyo Metropolitan Ebara General Hospital.

The Japanese Journal of Antibiotics
|March 1, 1988
PubMed
Summary

Ceftriaxone (CTRX) demonstrates favorable pharmacokinetics and safety in neonates, with effective treatment outcomes for various infections. Drug accumulation was not observed in premature infants receiving multiple doses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between the housing coldness/warmth evaluation by CASBEE Housing Health Checklist and psychological distress based on TMM Community-Based Cohort Study: a cross-sectional analysis.

Public health·2022
Same author

Surface-Specific Spectroscopy of Water at a Potentiostatically Controlled Supported Graphene Monolayer.

The journal of physical chemistry. C, Nanomaterials and interfaces·2019
Same author

Unrelated cord blood transplantation in aplastic anemia: is anti-thymocyte globulin indispensable for conditioning?

Bone marrow transplantation·2017
Same author

Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasm.

Leukemia·2017
Same author

Tuning the deposition of molecular graphene nanoribbons by surface functionalization.

Nanoscale·2015
Same author

Live-cell imaging study of mitochondrial morphology in mammalian cells exposed to X-rays.

Radiation protection dosimetry·2015

Area of Science:

  • Pediatric Pharmacology
  • Infectious Diseases
  • Neonatal Medicine

Context:

  • Neonates are a vulnerable population requiring specialized pharmacokinetic and safety data for antibiotic use.
  • Ceftriaxone is a third-generation cephalosporin commonly used for bacterial infections.

Purpose:

  • To clinically evaluate Ceftriaxone (CTRX) and study its pharmacokinetics in neonates.
  • To assess the efficacy and safety of CTRX in treating neonatal infections.

Summary:

  • Pharmacokinetic analysis showed varying blood levels and half-lives (T1/2) after single intravenous doses (10-20 mg/kg) and drip infusions.
  • No significant drug accumulation occurred in premature infants with multiple intravenous administrations.
  • Urinary excretion ranged from 13.8-58.5% within 6 hours post-administration.

Related Experiment Videos

  • CTRX demonstrated excellent or good efficacy in treating sepsis, pneumonia, and other infections in 9 neonates at daily doses of 19.5-41.6 mg/kg for 4-11 days.
  • No adverse effects were noted on blood counts, hepatic, or renal function.

    • Impact:

    • Provides essential pharmacokinetic and safety data for Ceftriaxone use in neonates.
    • Supports the clinical utility of Ceftriaxone in treating serious neonatal infections.
    • Highlights the favorable safety profile of Ceftriaxone in this population.