Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells
Bei-Bei Fu1, Jian-Nan Zhao2, Shuo-Dong Wu2
1Department of Health Management, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
Abstract:
Cholesterol gallstone (CG) is a common, frequent biliary system disease in China, with a complex and multifactorial etiology. Declined gallbladder motility reportedly contributes to CG pathogenesis. Furthermore, interstitial Cajal-like cells (ICLCs) are reportedly present in human and guinea pig gallbladder tissue. ICLCs potentially contribute to the regulation of gallbladder motility, and aberrant conditions involving the loss of ICLCs and/or a reduction in its pacing potential and reactivity to cholecystokinin may promote CG pathogenesis. This review discusses the association between ICLCs and CG pathogenesis and provides a basis for further studies on the functions of ICLCs and the etiologies of CG.
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