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Related Concept Videos

Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Cell Motility through Blebbing01:16

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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
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Maturation of Endosomes01:28

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The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
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Related Experiment Video

Updated: Nov 4, 2025

2D and 3D Matrices to Study Linear Invadosome Formation and Activity
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Tissue remodeling by invadosomes.

Alessandra Cambi1, Philippe Chavrier2

  • 1Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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|May 28, 2021
PubMed
Summary
This summary is machine-generated.

Invadosomes, including podosomes and invadopodia, are crucial for cell migration and extracellular matrix remodeling. Recent findings clarify their composition, dynamics, and in vivo functions in tissue remodeling.

Keywords:
Invadosomeactin cytoskeletoncell migrationinvadopodiumpodosome

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Pathophysiology

Background:

  • Cells remodel the extracellular matrix (ECM) using invadosomes, which are actin-based structures mediating proteolysis.
  • Podosomes are invadosomes in normal cells, while invadopodia are found in invasive cancer cells.

Purpose of the Study:

  • To discuss recent findings on the commonalities and differences between podosomes and invadopodia.
  • To propose an updated definition of these cellular protrusions.
  • To highlight their relevance in pathophysiological tissue remodeling.

Main Methods:

  • Literature review of recent findings on invadosome organization and function.
  • Analysis of studies investigating invadosomes in vitro and in vivo.
  • Comparative analysis of podosomes and invadopodia.

Main Results:

  • Invadosomes share common organizational and functional principles.
  • Podosomes and invadopodia exhibit distinct peculiarities in their composition and dynamics.
  • These cellular protrusions play significant roles in cell migration and ECM remodeling.

Conclusions:

  • An updated definition of invadosomes is proposed based on current knowledge.
  • Invadosomes are critical for both normal tissue remodeling and pathological conditions like cancer.
  • Further research is needed to fully understand their in vivo relevance.