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Cranial and Spinal Meninges

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...

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Related Experiment Video

Updated: Nov 4, 2025

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

[Post-dural puncture headache].

Katharina Kamm¹, Stefanie Förderreuther²

¹Neurologische Klinik und Poliklinik, Klinikum der LMU München, Standort Großhadern, Marchioninistr. 15, 81377, München, Deutschland.

|May 28, 2021

Summary

This summary is machine-generated.

Post-dural puncture headache is a common complication of dural puncture, causing orthostatic headaches. While typically benign and self-resolving, severe cases warrant attention.

Keywords:

Blood patch, epidural Caffeine Lumbar puncture/complications Post-dural puncture headache/pathophysiology Theophylline

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Area of Science:

Neurology
Neurosurgery

Background:

Post-dural puncture headache (PDPH) is a secondary headache disorder.
It is a common complication following dural puncture procedures.
Characterized by orthostatic headache and potential neurological symptoms.

Purpose of the Study:

To provide a comprehensive overview of PDPH.
To discuss current knowledge on pathophysiology, diagnosis, and treatment.

Main Methods:

Literature review of PDPH.
Synthesis of current evidence on pathophysiology, diagnostics, and therapy.

Main Results:

PDPH main symptom is orthostatic headache.
Neurological symptoms like diplopia can occur.
The condition is usually benign with spontaneous resolution.
Severe cases have been documented.

Conclusions:

Understanding PDPH pathophysiology is crucial for diagnosis and management.
Appropriate diagnostic work-up aids in identifying PDPH.
Therapeutic strategies can alleviate symptoms and manage severe cases.