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Updated: Nov 4, 2025

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
Published on: July 29, 2021
[Post-dural puncture headache]
Katharina Kamm1, Stefanie Förderreuther2
1Neurologische Klinik und Poliklinik, Klinikum der LMU München, Standort Großhadern, Marchioninistr. 15, 81377, München, Deutschland.
Abstract:
Post-dural puncture headache belongs to the group of secondary headache disorders and is a typical complication of intended or unintended dural puncture. The main symptom is orthostatic headache, which can be accompanied by neurological symptoms such as diplopia depending on the extent of the cerebrospinal fluid leak. The course of this headache is predominantly benign, showing spontaneous improvement over a couple of days, although severe cases are described in the literature. The following article provides an overview of the current knowledge about the headache's pathophysiology, diagnostic work-up and therapy.

