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Outcomes measures in idiopathic intracranial hypertension
Susan P Mollan1, Alexandra J Sinclair1,2,3,4
1Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, United Kingdom (UK).
Insights
Idiopathic intracranial hypertension (IIH) management requires standardized outcome measures. Optical coherence tomography shows promise for monitoring papilledema and visual function in IIH patients.
Area of Science:
- Neurology
- Ophthalmology
- Clinical Trials
Background:
- Idiopathic intracranial hypertension (IIH) presents with elevated intracranial pressure, papilledema, and normal neuroimaging.
- Key symptoms include chronic headaches and potential vision loss, highlighting unmet treatment needs.
Purpose of the Study:
- To review the evidence and expert opinion on outcome measures for successful idiopathic intracranial hypertension management.
- To identify and standardize appropriate endpoints for clinical trials in IIH.
Main Methods:
- Literature review of current evidence on IIH outcome measures.
- Expert opinion synthesis on the utility of various assessment tools.
Main Results:
- Optical coherence tomography (OCT) is emerging as a less invasive tool for assessing papilledema and potentially intracranial pressure.
- Standardized assessment of headache morbidity is crucial for comparing treatment efficacy.
Conclusions:
- OCT offers a promising surrogate for monitoring disease activity and visual function in IIH.
- Standardized outcome measures are essential for advancing IIH treatment research and clinical practice.
Abstract:
Introduction: Idiopathic intracranial hypertension is a condition characterized by raised intracranial pressure, papilledema, and normal neuroimaging (aside from radiological signs of raised intracranial pressure). Symptoms of idiopathic intracranial hypertension include chronic headaches and for some, visual loss. New treatments are unmet clinical needs.Areas covered: The aim of this review is to present the evidence base and considered opinion on outcome measures to determine successful management of idiopathic intracranial hypertension.Expert opinion: Less invasive measures of disease activity such as optical coherence tomography will continue to grow in this field, both as a measure of papilledema, and potentially as a surrogate for intracranial pressure and visual function. As a highly disabling aspect of the disease is headache, treatment outcomes for headache morbidity need to be appropriately chosen and standardized to allow comparison between trials.
