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Targeted perfusion adsorption for hyperphosphatemia using mixed matrix microspheres (MMMs) encapsulated
Wenhui Chen1, Qiu Han2, Yang Liu3
1Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, No. 1219 Zhongguan West Rd, Ningbo 315201, China. fu.liu@nimte.ac.cn and Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215000, China.
New mixed matrix microspheres effectively remove excess phosphate from blood, offering a promising treatment for hyperphosphatemia in chronic kidney disease patients. These materials show excellent adsorption and hemocompatibility.
Area of Science:
- Biomaterials Science
- Nephrology
- Materials Chemistry
Background:
- Hyperphosphatemia is a common complication in chronic renal failure, linked to serious health issues like vascular calcification.
- Current treatments for hyperphosphatemia have limitations in efficiency and can lead to secondary complications.
- Metal-organic frameworks (MOFs) show potential for blood purification due to their adsorption capabilities.
Purpose of the Study:
- To develop novel mixed matrix microspheres (MMMs) for enhanced phosphate removal.
- To improve hemocompatibility for safe application in blood purification.
- To evaluate the efficacy of NH2-MIL-101(Fe) encapsulated MMMs in phosphate adsorption.
Main Methods:
- Preparation of mixed matrix microspheres (MMMs) encapsulating NH2-MIL-101(Fe).
- Incorporation of a heparinoid copolymer (P(AA-SSNa)) to enhance hemocompatibility.
- Evaluation of phosphate adsorption capacity in aqueous and plasma environments.
- Assessment of hemocompatibility, including protein adsorption, hemolysis, and coagulation time.
Main Results:
- The developed MMMs demonstrated excellent phosphate adsorption capacity.
- MMMs showed high hemocompatibility, with low protein adsorption and hemolysis rates.
- Blood coagulation time was extended, indicating improved safety for hemoperfusion.
Conclusions:
- The synthesized MMMs are highly efficient phosphate adsorbents.
- These materials possess favorable hemocompatibility, crucial for blood purification applications.
- The MMMs show significant potential as hemoperfusion adsorbents for treating hyperphosphatemia.
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