Related Experiment Video

Updated: Nov 4, 2025

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
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Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells

Published on: July 30, 2020

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Aurora B kinase: a potential drug target for cancer therapy

Azaj Ahmed1, Anas Shamsi1, Taj Mohammad1

  • 1Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.

Journal of Cancer Research and Clinical Oncology
|May 28, 2021
PubMed
Abstract

Insights

Aurora B kinase (ABK) is crucial for cell division and maintaining genetic integrity. Inhibiting ABK shows promise for controlling cancer progression, with ongoing research into its therapeutic potential.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Biochemistry

Background:

  • Aurora kinases are essential serine/threonine kinases vital for maintaining genomic integrity during cell division.
  • Aberrant cell division, leading to aneuploidy, is a known cause of various malignancies.
  • Mammalian cells express three highly conserved aurora kinases that collaborate with other proteins to ensure accurate chromosome segregation.

Purpose of the Study:

  • To provide a comprehensive analysis of Aurora B kinase (ABK).
  • To explore ABK's expression, structure, function, and association with diseases.
  • To discuss the potential therapeutic implications of targeting ABK.

Main Methods:

  • Literature review and analysis of existing research on Aurora B kinase.
  • Examination of ABK's role in key mitotic processes.
  • Investigation of small-molecule inhibitors targeting ABK.

Main Results:

  • Aurora B kinase (ABK) is instrumental in mitotic entry, chromosome condensation, spindle assembly, cytokinesis, and abscission.
  • Small-molecule inhibitors targeting ABK have been developed to impede cancer progression.
  • Understanding ABK's role in cancer pathophysiology is critical for developing effective cancer therapies.

Conclusions:

  • The review discusses the physiological importance of ABK and its involvement in cancer.
  • Available small-molecule inhibitors for controlling tumor proliferation are highlighted.
  • Mechanistic insights into ABK inhibition for cancer therapy are presented.
Keywords:
AneuploidyAurora kinaseCancer therapeuticsCell cycle regulationSmall molecule inhibitors

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