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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Updated: Nov 4, 2025

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
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Diffusion-weighted imaging diagnostic algorithm in patients with suspected pleural malignancy.

Wenrui Jiang1, Zhiping Han1, Xing Tang2

  • 1Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, China.

European Radiology
|May 28, 2021
PubMed
Summary
This summary is machine-generated.

Diffusion-weighted imaging (DWI) offers higher sensitivity than CT for diagnosing pleural malignancy. Incorporating DWI into diagnostic algorithms can help avoid invasive procedures in select patients.

Keywords:
Diffusion magnetic resonance imagingPleural neoplasmsTomography, X-ray computed

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Pleural malignancy (PM) diagnosis can be challenging.
  • Computed tomography (CT) has limitations in differentiating benign from malignant pleural lesions.

Purpose of the Study:

  • To evaluate the diagnostic performance and clinical utility of diffusion-weighted imaging (DWI) for suspected pleural malignancy (PM).
  • To compare DWI with CT in diagnosing PM.

Main Methods:

  • Retrospective analysis of 70 patients with suspected PM who underwent chest DWI and CT.
  • Cytological or histopathological findings served as reference standards.
  • A three-step DWI diagnostic algorithm was developed and assessed.

Main Results:

  • DWI demonstrated significantly higher sensitivity (94.2%) than CT (67.3%) for PM detection, with comparable specificity.
  • Malignant lesions showed lower apparent diffusion coefficients than benign lesions, though overlap existed.
  • The DWI algorithm helped avoid invasive procedures in 62.5% of patients without advanced metastasis.

Conclusions:

  • DWI is a valuable tool for efficiently identifying pleural malignancy.
  • A DWI-based diagnostic algorithm can reduce unnecessary invasive procedures.
  • Hyperintense DWI signals at high b-values are indicative of PM.