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Related Experiment Video

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A Mouse Model of Candidiasis.

Pilar Fajardo1, Ana Cuenda1, Juan José Sanz-Ezquerro2

  • 1Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain.

Methods in Molecular Biology (Clifton, N.J.)
|May 28, 2021
PubMed
Summary
This summary is machine-generated.

This study details a mouse model for disseminated candidiasis, a systemic fungal infection. The protocol helps research inflammation and immune responses in severe Candida albicans infections.

Keywords:
Candida albicansCandidiasisFungal infectionInflammationMouse modelSepsis

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Area of Science:

  • * Immunology
  • * Mycology
  • * Infectious Diseases

Background:

  • * Disseminated candidiasis, a severe systemic fungal infection, poses significant health risks.
  • * The intravenous challenge model in mice effectively mimics human disseminated candidiasis, with kidneys as primary target organs.
  • * This model recapitulates renal failure and septic shock, mirroring severe clinical cases in humans.

Purpose of the Study:

  • * To describe a standardized intravenous challenge protocol for Candida albicans infection in mice.
  • * To detail the methodology for studying inflammation and host immune responses in disseminated fungal infections.
  • * To provide a comprehensive guide for researchers investigating systemic candidiasis.

Main Methods:

  • * Preparation of Candida albicans inoculum for intravenous injection.
  • * Monitoring of animal health and disease progression post-infection.
  • * Collection and preparation of tissue samples for analysis.
  • * Analysis of infection parameters and host inflammatory markers.

Main Results:

  • * The intravenous model reliably induces systemic Candida albicans infection in mice.
  • * Kidney damage and indicators of septic shock are observed, consistent with human disease.
  • * The model allows for detailed study of host-pathogen interactions and inflammatory pathways.

Conclusions:

  • * The described intravenous candidiasis model in mice is a valuable tool for studying disseminated fungal infections.
  • * This protocol facilitates research into host immune responses and therapeutic strategies for candidiasis.
  • * The model's ability to replicate human disease progression aids in understanding severe sepsis and inflammation.