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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
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Sepsis Biomarkers
Yachana Kataria1, Daniel Remick2
1Department of Pathology and Laboratory Medicine, Boston School of Medicine, Boston, MA, USA. Yachana.Kataria@bmc.org.
Methods in Molecular Biology (Clifton, N.J.)
|May 28, 2021
Summary
Current sepsis biomarkers lack the accuracy for definitive diagnosis in humans. While useful in animal models, single biomarkers are insufficient for ruling sepsis in or out in clinical settings.
Area of Science:
- Biomarkers
- Sepsis Diagnosis
- Prognosis
Background:
- Biomarkers are discrete molecules in blood used to aid sepsis diagnosis and prognosis.
- Current limitations in sensitivity and specificity hinder definitive sepsis diagnosis using single biomarkers in humans.
Purpose of the Study:
- To evaluate the diagnostic and prognostic utility of biomarkers in sepsis.
- To assess the performance of single biomarkers in clinical sepsis diagnosis.
Main Methods:
- Analysis of existing data on biomarker performance in sepsis.
- Review of studies utilizing discrete molecules in blood for sepsis assessment.
Main Results:
- Single biomarkers in 2020 lacked sufficient sensitivity and specificity for definitive sepsis diagnosis.
- Biomarkers demonstrated improved performance in animal models of sepsis compared to human clinical data.
Conclusions:
- Single biomarkers are currently inadequate for definitively ruling sepsis in or out in human patients.
- Further research is needed to improve the accuracy of sepsis biomarkers in clinical practice.
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