Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

473
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
473
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

287
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
287

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PATIENT TESTIMONIALS-A NEW INTERACTIVE FORMAT FOR DIALOG BETWEEN SHOCK MEMBERS AND PATIENTS.

Shock (Augusta, Ga.)·2025
Same author

The 2024 PhD Board-Certified Clinical Chemist Compensation Survey.

The journal of applied laboratory medicine·2025
Same author

A Meta-analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Anti-spike Immunoglobulin G Antibody Durability up to 9 Months After Full Vaccination in Adults.

Clinics in laboratory medicine·2025
Same author

High-Sensitivity and Conventional Cardiac Troponin-I Assays in AL Amyloidosis.

The journal of applied laboratory medicine·2024
Same author

GENETIC ABLATION OF THE C-TYPE LECTIN RECEPTOR CLEC2D INCREASES PERITONITIS MORTALITY, INFLAMMATION, AND PHYSIOLOGY WITHOUT DIMINISHING ORGAN INJURY.

Shock (Augusta, Ga.)·2024
Same author

Author's response: What determines the success of generating multiple-choice questions.

Academic pathology·2024

Related Experiment Video

Updated: Nov 4, 2025

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

3.9K

Sepsis Biomarkers.

Yachana Kataria1, Daniel Remick2

  • 1Department of Pathology and Laboratory Medicine, Boston School of Medicine, Boston, MA, USA. Yachana.Kataria@bmc.org.

Methods in Molecular Biology (Clifton, N.J.)
|May 28, 2021
PubMed
Summary
This summary is machine-generated.

Current sepsis biomarkers lack the accuracy for definitive diagnosis in humans. While useful in animal models, single biomarkers are insufficient for ruling sepsis in or out in clinical settings.

Keywords:
AntibioticsC-reactive proteinIL-6ProcalcitoninSepsis

More Related Videos

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

12.1K
A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

366

Related Experiment Videos

Last Updated: Nov 4, 2025

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

3.9K
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

12.1K
A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

366

Area of Science:

  • Biomarkers
  • Sepsis Diagnosis
  • Prognosis

Background:

  • Biomarkers are discrete molecules in blood used to aid sepsis diagnosis and prognosis.
  • Current limitations in sensitivity and specificity hinder definitive sepsis diagnosis using single biomarkers in humans.

Purpose of the Study:

  • To evaluate the diagnostic and prognostic utility of biomarkers in sepsis.
  • To assess the performance of single biomarkers in clinical sepsis diagnosis.

Main Methods:

  • Analysis of existing data on biomarker performance in sepsis.
  • Review of studies utilizing discrete molecules in blood for sepsis assessment.

Main Results:

  • Single biomarkers in 2020 lacked sufficient sensitivity and specificity for definitive sepsis diagnosis.
  • Biomarkers demonstrated improved performance in animal models of sepsis compared to human clinical data.

Conclusions:

  • Single biomarkers are currently inadequate for definitively ruling sepsis in or out in human patients.
  • Further research is needed to improve the accuracy of sepsis biomarkers in clinical practice.