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Analgesia and Humane Endpoints for Rodents in Sepsis Research
Christine A Boehm1, Jean A Nemzek2
1Laboratory Animal Research Center, Texas Tech University Health Sciences Center at El Paso, El Paso, TX, USA. boehmec@gmail.com.
Methods in Molecular Biology (Clifton, N.J.)
|May 28, 2021
Abstract:
Numerous regulatory bodies around the world require analgesics for rodents undergoing surgery to induce sepsis. Well-controlled pain will decrease morbidity. Options for analgesics include NSAIDs, local analgesics, and opioids. Supportive care can also decrease stress to post-operative animals. As well, humane endpoints should be agreed upon before the study commences so as to alleviate unnecessary pain and distress.
Keywords:
AnalgesiaCecal ligation and punctureCecal slurryColon ascendens stent peritonitis and fibrin clot implantationHumane endpointsMouseSepsis
