Related Experiment Video
Updated: Nov 4, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.4K
Summary
Migraine is a complex brain disorder involving sensory processing and homeostatic dysregulation. Recent research clarifies its pathophysiology, aiding targeted therapy development.
Area of Science:
- Neuroscience
- Neurology
- Pathophysiology
Background:
- Migraine is a complex neurological disorder.
- Understanding migraine pathophysiology is crucial for developing effective treatments.
Purpose of the Study:
- To summarize current knowledge on migraine pathophysiology.
- To discuss controversial aspects of migraine mechanisms.
- To review the mechanisms underlying clinical manifestations in each migraine phase.
Main Methods:
- Review of functional neuroimaging studies.
- Analysis of clinical studies on spontaneous and provoked attacks.
- Examination of preclinical studies using translational animal models.
Main Results:
- Functional neuroimaging identifies key central nervous system areas in early migraine phases.
- Clinical and preclinical studies enhance understanding of migraine disease.
- Development of disease-specific and targeted migraine therapies is progressing.
Conclusions:
- Migraine is a complex cyclical brain disorder.
- Dysfunctional sensory processing and dysregulated homeostatic mechanisms are implicated.
- Advances in understanding pathophysiology are driving targeted therapeutic development.
Related Concept Videos
01:22Pathophysiology of Vomiting
1.7K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
1.7K
01:20Asthma: Pathogenesis and Management
901
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
901
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.3K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.3K
01:29Hypertension II: Pathophysiology
274
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
274
01:19Ion Channels
89.5K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
89.5K
01:26Asthma-II: Pathophysiology and Classification
3.5K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.5K