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Related Concept Videos

Preventive Healthcare Services01:30

Preventive Healthcare Services

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Cholinergic Antagonists: Therapeutic Uses01:26

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Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:    
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Preventive Migraine Treatment.

Rebecca Burch

    Continuum (Minneapolis, Minn.)
    |May 28, 2021
    PubMed
    Summary

    Newer treatments targeting the calcitonin gene-related peptide (CGRP) pathway offer effective migraine prevention. While generally well-tolerated, real-world data suggests potential for more adverse events than in clinical trials.

    Area of Science:

    • Neurology
    • Pharmacology
    • Medical Interventions

    Background:

    • Migraine is a debilitating neurological condition impacting quality of life.
    • Preventive treatments aim to reduce migraine frequency and severity.
    • The landscape of migraine prevention has evolved significantly with new therapeutic targets.

    Purpose of the Study:

    • To provide a comprehensive overview of current migraine preventive interventions.
    • To guide clinicians on initiating and selecting appropriate migraine prevention strategies.
    • To discuss pharmacologic and non-pharmacologic options, including novel therapies.

    Main Methods:

    • Review of recent clinical trials and real-world studies on migraine prevention.
    • Analysis of pharmacologic treatments, including monoclonal antibodies to CGRP and oral gepants.

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  • Evaluation of non-pharmacologic interventions such as neuromodulation devices.

    • Main Results:

    • Monoclonal antibodies targeting CGRP/receptor show high efficacy but may have higher adverse event rates in real-world use.
    • Established oral preventive medications (lisinopril, candesartan, memantine) have supporting evidence.
    • Neuromodulation devices demonstrate modest evidence for preventive efficacy.
    • New oral CGRP receptor antagonists (gepants) are under investigation for prevention.

    Conclusions:

    • Effective migraine prevention significantly reduces disease burden and improves patient quality of life.
    • A range of pharmacologic and non-pharmacologic options exist for migraine prevention.
    • Individualized treatment selection is crucial, potentially requiring multiple trials to identify the optimal preventive therapy.