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Plasma GDF-15 concentration is not elevated in open-angle glaucoma.

Wouter H G Hubens1,2, Mariëlle T Kievit1,2, Tos T J M Berendschot1,3

  • 1University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.

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This summary is machine-generated.

Plasma growth differentiation factor 15 (GDF-15) is not a reliable biomarker for detecting mitochondrial dysfunction in open-angle glaucoma (OAG) patients, even after accounting for confounding factors like age and hypertension.

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Area of Science:

  • Ophthalmology
  • Biochemistry
  • Mitochondrial Biology

Background:

  • Mitochondrial dysfunction is implicated in the pathophysiology of open-angle glaucoma (OAG).
  • Growth differentiation factor 15 (GDF-15) has been proposed as a biomarker for mitochondrial dysfunction.

Purpose of the Study:

  • To evaluate plasma GDF-15 as a biomarker for mitochondrial dysfunction in OAG patients.
  • To investigate the relationship between GDF-15 levels and OAG, including high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) subtypes.

Main Methods:

  • Plasma GDF-15 concentrations were measured using ELISA in 200 OAG patients and 61 controls.
  • Statistical analysis included Kruskal-Wallis test and forward linear regression to identify and correct for confounders (age, gender, smoking, hypertension).

Main Results:

  • Initially, lower GDF-15 levels were observed in the combined OAG group (p=0.04), but not in separate HTG/NTG analyses.
  • After correcting for confounders, no significant difference in GDF-15 levels was found between OAG patients and controls.
  • In NTG patients, dietary supplement intake correlated with lower GDF-15 levels.

Conclusions:

  • Plasma GDF-15 is not a suitable biomarker for mitochondrial dysfunction in OAG.
  • Confounding factors significantly influence GDF-15 levels in OAG patients.