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Updated: Nov 4, 2025

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
Published on: January 20, 2012
Editorial: The Complexity of Neurofeedback and Control of Placebo Effects
1Dr. Aggensteiner is with the Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Abstract:
The Neurofeedback Collaborative Group1 made substantial efforts in assessing clinical effects of neurofeedback (NF) as a promising nonpharmacological treatment option for attention-deficit/hyperactivity disorder (ADHD). In a double-blind, placebo-controlled randomized clinical trial (RCT), they evaluated the specific effects of a standard NF protocol (theta/beta ratio [TBR] training) compared to a placebo-like control group. Similar to pharmacological studies, the placebo-like intervention can be considered as a gold standard, as it allows evaluation of specific effects of NF training.
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