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Updated: Nov 4, 2025
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Brain volumetric and fractal analysis of synthetic MRI: A comparative study with conventional 3D T1-weighted images
Sidong Liu1, Tiebao Meng2, Carlo Russo3
1Computational NeuroSurgery (CNS) Lab, Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia; Australian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.
Purpose:
The estimation of brain volumetric measurements based on Synthetic MRI (SyMRI) is easy and fast, however, the consistency of brain volumetric and morphologic measurements based on SyMRI and 3D T1WI should be further addressed. The current study evaluated the impact of spatial resolution on brain volumetric and morphologic measurements using SyMRI, and test whether the brain measurements derived from SyMRI were consistent with those resulted from 3D T1WI.
Method:
Brain volumetric and fractal analysis were applied to thirty healthy subjects, each underwent four SyMRI acquisitions with different spatial resolutions (1 × 1 × 2 mm, 1 × 1x3mm, 1 × 1 × 4 mm, 2 × 2 × 2 mm) and a 3D T1WI (1 × 1 × 1 mm isotropic). The consistency of the SyMRI measurements was tested using one-way non-parametric Kruskal-Wallis test and post hoc Dwass-Steel-Critchlow-Fligner test. The association between SyMRI and 3D T1WI derived measurements was evaluated using linear regression models.
Results:
Our results demonstrated that both in- and through-plane resolutions show an impact on brain volumetric measurements, while brain parenchymal volume showed high consistency across the SyMRI acquisitions, and high association with the measurements from 3D T1WI. In addition, SyMRI with 1 × 1 × 4 mm resolution showed the strongest association with 3D T1WI compared to other SyMRI acquisitions in both volumetric and fractal analyses. Moreover, substantial differences were found in fractal dimension of both gray and white matter between the SyMRI and 3D T1WI tissue segmentations.
Conclusions:
Our results suggested that the measurements from SyMRI with relatively higher in-plane and lower through-plane resolution (1 × 1 × 4 mm) are much closer to 3D T1WI.
