[Optic papilla parameters in healthy subjects--quantified with the optic nerve head analyzer]

Area of Science:

• Ophthalmology
• Optic Nerve Head Imaging
• Glaucoma Research

Context:

• Accurate measurement of optic nerve head (ONH) parameters is crucial for diagnosing and monitoring optic neuropathies.
• Standardization of ONH measurements is needed for reliable clinical assessment and research.
• The Optic Nerve Head Analyzer (ONHA) offers a tool for quantitative ONH analysis.

Purpose:

• To establish normative values for optic disk parameters, including cup-disk ratio (CDR) and neuroretinal rim area, in healthy eyes.
• To introduce a novel method for calculating average optic disk pallor.
• To investigate the interrelationships between various ONH parameters using multi-regressional analysis.

Summary:

• Double examinations of 32 healthy eyes using the ONHA determined normal values for CDR, neuroretinal rim area, and other disk parameters.
• A new method for calculating average disk pallor was presented, and its mean value in healthy eyes was determined.
• Multi-regressional analysis revealed that neuroretinal rim area size in healthy eyes is influenced by disk size, disk volume, and elevation volume.
• A significant interdependence was found between neuroretinal rim area and disk size, indicating larger disks have larger rim areas.
• Relative values, such as CDR and the rim area/disk area ratio, are recommended for comparing neuroretinal rim areas across different disk sizes.

Impact:

• Provides normative data for optic nerve head parameters, aiding in the detection of glaucomatous changes.
• Highlights the importance of considering disk size when comparing neuroretinal rim areas, promoting more accurate assessments.
• The proposed pallor calculation method and the emphasis on relative values enhance the standardization and comparability of ONH measurements in clinical practice and research.