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Related Experiment Videos

Complement-mediated pulmonary edema in sheep.

T M Egan1, N R Saunders, S C Luk

  • 1Department of Surgery, University of Toronto, Ontario, Canada.

The Journal of Surgical Research
|August 1, 1988
PubMed
Summary
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Zymosan-activated plasma (ZAP) infusion causes reversible lung edema and may alter protein permeability in sheep lungs. This study investigates the immediate effects of ZAP on pulmonary function and fluid dynamics.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Pathophysiology

Background:

  • Complement activation by zymosan leads to zymosan-activated plasma (ZAP).
  • ZAP infusion in sheep pulmonary circulation causes increased vascular resistance and hypoxemia.
  • Thromboxane, a vasoactive prostaglandin, is implicated in ZAP-induced responses.

Purpose of the Study:

  • To investigate if ZAP infusion causes pulmonary edema.
  • To determine if ZAP infusion transiently alters pulmonary protein permeability.

Main Methods:

  • Open lung biopsies and electron microscopy in three sheep during ZAP infusion.
  • Lung lymph fistula preparation and monitoring in three other sheep during ZAP infusion.

Main Results:

Related Experiment Videos

  • Electron microscopy confirmed early, reversible interstitial pulmonary edema.
  • ZAP infusion led to a rapid increase in lung lymph flow and lymph protein clearance.

Conclusions:

  • ZAP infusion induces rapid, reversible interstitial edema in the sheep lung.
  • Pulmonary protein permeability appears to be transiently altered by ZAP infusion.