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Related Experiment Video

Updated: Nov 4, 2025

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

Iatrogenic cerebral radiation necrosis.

Carolina Maria Helena Hilton¹, Lena Specht¹, Eva Loebner Lund²

¹Department of Oncology, Rigshospitalet, København, Denmark.

Practical Neurology

|May 29, 2021

Summary

Cerebral radiation necrosis, a severe brain complication from radiation therapy, often has poor treatment outcomes. Bevacizumab showed promise in improving neurological and radiological symptoms in a patient with this condition.

Keywords:

MR cerebrovascular neuropathology radiotherapy

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Published on: October 18, 2011

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Area of Science:

Neurology
Oncology
Radiology

Background:

Cerebral radiation necrosis is a significant late complication following brain radiotherapy.
Current treatment options for cerebral radiation necrosis are often limited and unsatisfactory.

Observation:

A patient developed cerebral radiation necrosis after prolonged fluoroscopic exposure during embolization procedures for an extracranial arteriovenous malformation.
The patient's condition was monitored following treatment.

Findings:

Treatment with bevacizumab, an antibody targeting vascular endothelial growth factor, led to notable improvements.
Neurological deficits and radiological evidence of necrosis showed positive changes after bevacizumab administration.

Implications:

Bevacizumab may represent a viable therapeutic option for managing cerebral radiation necrosis.
Further research into bevacizumab's efficacy and safety in treating radiation-induced brain injury is warranted.