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Prevotella diversity, niches and interactions with the human host
Adrian Tett1, Edoardo Pasolli2,3, Giulia Masetti4
1Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.
Nature Reviews. Microbiology
|May 29, 2021
Summary
Prevotella species are abundant in the human microbiome, influencing health and disease. Host diet and lifestyle impact Prevotella
Area of Science:
- Microbiome research
- Human health and disease
Background:
- The genus Prevotella comprises over 50 species, predominantly found in human-associated environments.
- Prevotella species are key members of the human microbiome, significantly impacting the host's health-disease balance.
Purpose of the Study:
- To review the diversity, prevalence, and host associations of Prevotella species.
- To highlight the role of genomic analysis in understanding Prevotella's ecological functions.
- To explore the influence of Western lifestyle and diet on the host-Prevotella relationship.
Main Methods:
- Literature review focusing on Prevotella diversity, prevalence, and host interactions.
- Analysis of genomic data to infer ecological roles.
- Synthesis of current knowledge on host-microbiome dynamics related to Prevotella.
Main Results:
- Prevotella species exhibit significant diversity and prevalence across various human body sites.
- Host factors like diet, lifestyle, and geography critically shape Prevotella composition.
- Genomic insights are crucial for elucidating Prevotella's contribution to human metabolism and health.
Conclusions:
- Prevotella plays a vital role in the human microbiome, with its impact modulated by host-specific factors.
- Understanding the host-Prevotella symbiotic relationship is essential for maintaining human health.
- Further research, particularly utilizing genomic approaches, is needed to fully define Prevotella's functions and its interaction with modern lifestyles.
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