Echo Time-Dependent Observed Lung T₁ in Patients With Chronic Obstructive Pulmonary Disease in Correlation With...

There is a clinical need for imaging-derived biomarkers for the management of chronic obstructive pulmonary disease (COPD). Observed pulmonary T₁ (T₁ (TE)) depends on the echo-time (TE) and reflects regional pulmonary function.

To investigate the potential diagnostic value of T₁ (TE) for the assessment of lung disease in COPD patients by determining correlations with clinical parameters and quantitative CT.

Prospective non-randomized diagnostic study.

Thirty COPD patients (67.7 ± 6.6 years). Data from a previous study (15 healthy volunteers [26.2 ± 3.9 years) were used as reference.

Study participants were examined at 1.5 T using dynamic contrast-enhanced three-dimensional gradient echo keyhole perfusion sequence and a multi-echo inversion recovery two-dimensional UTE (ultra-short TE) sequence for T₁ (TE) mapping at TE_1-5  = 70 μsec, 500 μsec, 1200 μsec, 1650 μsec, and 2300 μsec.

Perfusion images were scored by three radiologists. T₁ (TE) was automatically quantified. Computed tomography (CT) images were quantified in software (qCT). Clinical parameters including pulmonary function testing were also acquired.

Spearman rank correlation coefficients (ρ) were calculated between T₁ (TE) and perfusion scores, clinical parameters and qCT. A P-value <0.05 was considered statistically significant.

Median values were T₁ (TE_1-5 ) = 644 ± 78 msec, 835 ± 92 msec, 835 ± 87 msec, 831 ± 131 msec, 893 ± 220 msec, all significantly shorter than previously reported in healthy subjects. A significant increase of T₁ was observed from TE₁ to TE₂ , with no changes from TE₂ to TE₃ (P = 0.48), TE₃ to TE₄ (P = 0.94) or TE₄ to TE₅ (P = 0.02) which demonstrates an increase at shorter TEs than in healthy subjects. Moderate to strong Spearman's correlations between T₁ and parameters including the predicted diffusing capacity for carbon monoxide (DLCO, ρ < 0.70), mean lung density (MLD, ρ < 0.72) and the perfusion score (ρ > -0.69) were found. Overall, correlations were strongest at TE₂ , weaker at TE₁ and rarely significant at TE₄ -TE₅ .

In COPD patients, the increase of T₁ (TE) with TE occurred at shorter TEs than previously found in healthy subjects. Together with the lack of correlation between T₁ and clinical parameters of disease at longer TEs, this suggests that T₁ (TE) quantification in COPD patients requires shorter TEs. The TE-dependence of correlations implies that T₁ (TE) mapping might be developed further to provide diagnostic information beyond T₁ at a single TE.

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