Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carbon Nanodots and Their Performance in Powder and Coated Fabrics Forms for Industrial Wastewater Treatment.

Water environment research : a research publication of the Water Environment Federation·2026
Same author

Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination.

Nature communications·2026
Same author

Self-sustaining media-reconstituted GelMA bioink supports printable hematopoietic cultures.

Biomaterials science·2026
Same author

Smart biomaterials for cardiovascular, bone, and skin tissue engineering: mechanisms, applications, and future prospects.

Journal of biological engineering·2026
Same author

Scaffolds with spatiotemporally controlled growth factor delivery and cyclodextrin-enabled antagonism of growth factor receptor sequestration promote cutaneous wound healing.

NPJ Regenerative medicine·2025
Same author

Sciatic Nerve Regeneration in Rat Model With PLGA-MWCNT Conduit Loaded by Fibrin Hydrogel Containing Nanolycopene and Schwann Cells.

Journal of biomedical materials research. Part B, Applied biomaterials·2025

Related Experiment Video

Updated: Nov 4, 2025

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.5K

3D-Printed Hydrogel-Filled Microneedle Arrays.

Lindsay Barnum1,2, Jacob Quint1,2, Hossein Derakhshandeh1

  • 1Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.

Advanced Healthcare Materials
|May 29, 2021
PubMed
Summary

This study introduces novel microneedle arrays (MNAs) combining rigid outer layers with drug-eluting hydrogels. This innovation enables controlled transdermal drug delivery for diverse therapeutic applications.

Keywords:
chronic woundshydrogelsminiaturized needle arrayswound dressings

More Related Videos

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.6K
An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.3K

Related Experiment Videos

Last Updated: Nov 4, 2025

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.5K
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.6K
An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.3K

Area of Science:

  • Biomaterials Science
  • Drug Delivery
  • Nanotechnology

Background:

  • Microneedle arrays (MNAs) offer efficient transdermal drug delivery.
  • Hydrogels provide controlled therapeutic release but lack mechanical strength for skin penetration.
  • Combining MNAs and hydrogels has been a significant challenge in drug delivery.

Purpose of the Study:

  • To develop a robust strategy for combining MNAs and hydrogels for transdermal drug delivery.
  • To create multicomponent MNAs capable of delivering various agents to different tissue depths.
  • To enable tunable spatial and temporal control over drug release.

Main Methods:

  • Fabrication of MNAs with a rigid, 3D-printed outer layer on a conformal backing.
  • Filling the MNAs with drug-eluting hydrogels.
  • Utilizing microneedles of varying lengths for differential tissue depth delivery.
  • Controlling release kinetics via hydrogel composition and needle geometry.

Main Results:

  • Successful development of a low-cost, robust MNA system integrating hydrogels.
  • Demonstrated ability to create MNAs with variable needle lengths on a single patch.
  • Proof-of-concept delivery of vascular endothelial growth factor (VEGF) using the developed MNAs.
  • The rigid outer layer accommodates hydrogels of any mechanical property.

Conclusions:

  • The developed multicomponent MNAs overcome the limitations of traditional hydrogels for transdermal delivery.
  • This platform offers precise spatial and temporal control over drug release.
  • The technology is suitable for a wide range of transdermal drug delivery applications.