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Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface
Published on: October 8, 2013
Long-term residential exposure to air pollution and Hodgkin lymphoma risk among adults in Denmark: a population-based
Tahir Taj1, Aslak Harbo Poulsen2, Matthias Ketzel3,4
1Danish Cancer Society Research Center, Diet, Genes and Environment Strandboulevarden 49, 2100, Copenhagen, Denmark. tahir@cancer.dk.
Purpose:
The etiology of Hodgkin lymphoma (HL) is obscure. Research on air pollution and risk of HL provides inconsistent results. We aimed to investigate the association between long-term residential exposure to air pollution and risk of adult Hodgkin lymphoma in Denmark.
Methods:
We performed a nationwide register-based case-control study, including all (n = 2,681) Hodgkin lymphoma cases registered in the nationwide Danish Cancer Registry between 1989 and 2014. We randomly selected 8,853 age- and sex-matched controls from the entire Danish population using the Civil Registration System, and identified 20-year residential address history for all cases and controls. We modeled outdoor air pollution concentrations at all these addresses using the high-resolution multiscale air pollution model system DEHM/UBM/AirGIS. We used conditional logistic regression to estimate odds ratios adjusted for individual and neighborhood level sociodemographic variables.
Results:
There was no association between 1, 5, 10, and 20 years' time-weighted average exposure to fine particles (PM2.5), O3, SO2, NO2, or the PM2.5 constituents OC, NH4, NO3, and SO4 and risk of Hodgkin lymphoma.
Conclusion:
Residential exposure to ambient air pollution does not seem to increase the risk of developing Hodgkin lymphoma.
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