Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

293
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
293
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

560
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
560
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

620
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
620

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current status of radionuclide therapy targeting PARP in cancer: challenges and prospects.

European journal of nuclear medicine and molecular imaging·2026
Same author

Bridging the gaps in fibroblast activation protein targeted radionuclide therapy: a translational perspective.

European journal of nuclear medicine and molecular imaging·2026
Same author

Differential [<sup>18</sup>F]FAPI-42 and [<sup>18</sup>F]FDG uptake patterns distinguish desmoid tumours from GISTs on PET/CT imaging.

European journal of nuclear medicine and molecular imaging·2026
Same author

A novel synergistic drug combination of a mitogen-activated extracellular signal-regulated kinase inhibitor with [<sup>177</sup>Lu]Lu-rhPSMA-10.1 for prostate cancer treatment: Results of a preclinical evaluation.

Nuclear medicine and biology·2025
Same author

LnDOTA Releasing Probes for Luminescence and Magnetic Resonance Imaging.

Inorganic chemistry·2025
Same author

Preclinical Evaluation of <sup>177</sup>Lu-rhPSMA-10.1, a Radiopharmaceutical for Prostate Cancer: Biodistribution and Therapeutic Efficacy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025

Related Experiment Video

Updated: Nov 4, 2025

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
10:54

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

Published on: February 4, 2017

8.3K

Emerging chelators for nuclear imaging.

Deborah Sneddon1, Bart Cornelissen1

  • 1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, OX3 7LE, United Kingdom.

Current Opinion in Chemical Biology
|May 29, 2021
PubMed
Summary

New chelators are needed for nuclear medicine imaging as radiometals expand. The ideal chelator allows mild labeling conditions and offers superior stability for targeted delivery, improving upon current standards like DOTA.

Keywords:
Lutetium-177 radiopharmaceuticalPETScandium-44Zirconium-89

More Related Videos

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

9.0K
Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

Published on: November 20, 2018

6.7K

Related Experiment Videos

Last Updated: Nov 4, 2025

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
10:54

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

Published on: February 4, 2017

8.3K
Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

9.0K
Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

Published on: November 20, 2018

6.7K

Area of Science:

  • Nuclear medicine
  • Radiopharmaceutical chemistry
  • Chelation therapy

Background:

  • Chelators are crucial for directing radiometals in nuclear medicine imaging.
  • The current gold standard, 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), requires harsh conditions for radiometal chelation.
  • Expanding radiometal options necessitate novel chelators to prevent off-target effects and improve targeting specificity.

Purpose of the Study:

  • To highlight the need for improved chelators in radiometal-based nuclear medicine.
  • To identify the limitations of existing chelators, such as DOTA, under physiological conditions.
  • To emphasize the development of new chelators with superior properties for future clinical applications.

Main Methods:

  • Review of recent advancements in chelator development for radiometals.
  • Analysis of chelator properties including thermodynamic and kinetic stability.
  • Evaluation of labeling conditions, focusing on mild pH and temperature requirements.

Main Results:

  • The development of several novel chelators over the past 2-3 years.
  • These new chelators exhibit properties superior to DOTA for specific applications.
  • Potential for improved radiometal chelation under mild, near-neutral pH and low temperature conditions (∼37 °C).

Conclusions:

  • Novel chelators offer promising alternatives to DOTA for radiometal complexation.
  • The ideal chelator enables efficient radiolabeling under mild physiological conditions.
  • These advancements are critical for expanding the clinical utility of radiometal-based nuclear medicine imaging and therapies.