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Updated: Nov 4, 2025

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

ViBiBa: Virtual BioBanking for the DETECT multicenter trial program - decentralized storage and processing.

H Asperger¹, J-P Cieslik¹, B Alberter²

¹Department of Obstetrics and Gynecology, University Hospital Duesseldorf, Moorenstraße 5, Düsseldorf, Germany.

Translational Oncology

|May 29, 2021

Summary

This summary is machine-generated.

A new virtual bio-banking web-application, ViBiBa, streamlines data management for liquid biopsy (LB) specimens. This tool enhances collaboration and data accessibility for circulating tumor cell (CTC) research, overcoming challenges in decentralized sample collection.

Keywords:

CTC Liquid biopsy ViBiBa Virtual biobanking

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Last Updated: Nov 4, 2025

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

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Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

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Published on: September 11, 2023

Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Area of Science:

Oncology
Bioinformatics
Translational Research

Background:

Liquid biopsy (LB) offers a non-invasive method for cancer management, particularly using circulating tumor cells (CTCs).
Clinical utility of CTCs is hindered by low detection rates and numbers, especially in metastatic cases.
Decentralized sample collection in multicenter trials necessitates robust data management for translational research.

Purpose of the Study:

To develop a custom, browser-based virtual database for harmonizing and organizing LB specimens.
To enable the collection of clinically meaningful LB samples within the DETECT clinical CTC trials.
To facilitate high-quality translational CTC research through improved data management.

Main Methods:

Development of an open-source virtual bio-banking web-application named ViBiBa.
Automated processing of data from multiple, non-standardized sources.
Harmonization and merging of data into a centralized, searchable, multilayered database.

Main Results:

ViBiBa automatically processes and validates data from diverse sources.
Centralized databank enables extraction of clinically relevant patient cohorts and CTC sample collections.
The application provides a user-friendly, structured solution for decentralized sample storage.

Conclusions:

ViBiBa is a flexible tool supporting decentralized liquid biopsy specimen storage.
It promotes collaboration in a user-friendly, federalist, and structured manner.
The source code is publicly available under the MIT license.