Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Single-Strand DNA Binding Proteins

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...

DNA Packaging

DNA Packaging

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

The Replisome

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...

DNA Helicases

DNA Helicases

DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...

Lagging Strand Synthesis

Lagging Strand Synthesis

During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Validation of full-length radiograph based musculoskeletal modeling method to estimate medial and lateral knee contact forces.

Gait & posture·2024

Same author

The heterogeneity of physiological activity for chiral carbon dots derived from L/D/DL-arginine.

Journal of materials chemistry. B·2024

Same author

Magnetic Induction Heating in a Conducting Polymer for Biomedical Applications.

ACS nano·2024

Same author

Comparative phylogenomic study of East Asian endemic genus, Corchoropsis Siebold & Zucc. (Malvaceae s.l.), based on complete plastome sequences.

BMC genomics·2024

Same author

A high-quality genome assembly of the shrubby cinquefoil (Dasiphora fruticosa).

Scientific data·2024

Same author

Shifts in reproductive strategies in the evolutionary trajectory of plant lineages.

Science China. Life sciences·2024

Same journal

An interpretable framework for cancer drug response prediction using integrated drug and multi-omics data with a hybrid Bi-LSTM-GRU network.

Computational biology and chemistry·2026

Same journal

SegMWB: A lightweight deep learning framework for microscopic image classification.

Computational biology and chemistry·2026

Same journal

Protein dynamic simulations: From early inception to clinical translation over half a century.

Computational biology and chemistry·2026

Same journal

Integrated omics and virtual screening predict Tabularin as a dual inhibitor of the prognostic microRNAs mir-19a and mir-32 in colorectal cancer.

Computational biology and chemistry·2026

Same journal

In silico characterization of acetyl-CoA carboxylase from Staphylococcus aureus and Escherichia coli: A comparative analysis.

Computational biology and chemistry·2026

Same journal

An optimized cascaded transformer with progressive attention for lung and colon cancer diagnosis from histopathological images.

Computational biology and chemistry·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 4, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

An assembling strategy for DNA cages with minimum strands.

Tao Deng¹, Zhengxing Man², Weilan Wang³

¹Key Laboratory of China's Ethnic Languages and Information Technology of Ministry of Education, Northwest Minzu University, Lanzhou, 730030, China; Key Laboratory of Streaming Data Computing Technologies and Application, Northwest Minzu University, Lanzhou, 730030, China; School of Mathematics and Computer Science, Northwest Minzu University, Lanzhou, 730030, China.

Computational Biology and Chemistry

|May 29, 2021

Summary

This summary is machine-generated.

Researchers developed a computer algorithm to efficiently design DNA polyhedra using minimal DNA strands. This method accelerates the creation of complex DNA cages with specific topological structures.

Keywords:

DNA polyhedra Minimum strands Topological structures

More Related Videos

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Related Experiment Videos

Last Updated: Nov 4, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Area of Science:

* Synthetic biology
* Nanotechnology
* Computational chemistry

Background:

* DNA polyhedra are artificial cage-like structures formed by interlocked DNA double-strands.
* Efficient construction of DNA cages is crucial for designing single-stranded DNA molecules.
* Topological aspects of DNA polyhedron construction are not well understood.

Purpose of the Study:

* To theoretically propose an assembling strategy for DNA polyhedra using a minimum number of DNA strands.
* To develop a computer algorithm for efficient DNA polyhedron construction.
* To provide insights into designing DNA polyhedra with specific topological structures.

Main Methods:

* Theoretical proposal of a novel assembling strategy.
* Utilization of a computer algorithm for searching and designing DNA polyhedra.
* Focus on minimizing the number of DNA strands required for construction.

Main Results:

* The developed method efficiently searches for DNA polyhedra with fewer strands.
* The algorithm accelerates the discovery of minimal strand DNA polyhedra.
* Successful theoretical design of DNA polyhedra with fewer strands.

Conclusions:

* The proposed computer-aided strategy enables efficient design of DNA polyhedra with minimal strands.
* This research advances the understanding of topological construction for DNA cages.
* New insights are provided for the synthesis of DNA polyhedra with desired topological properties.