Related Experiment Video

Updated: Nov 4, 2025

State of the Art Cranial Ultrasound Imaging in Neonates
10:02

State of the Art Cranial Ultrasound Imaging in Neonates

Published on: February 2, 2015

25.1K

Transcranial Doppler Ultrasonography Imaging Studies in Children with Sickle Cell Anaemia in a Tertiary Hospital,

R Mohammed-Nafi'u1, O Oniyangi1, A O Akano2

  • 1Department of Paediatrics, National Hospital, Abuja, Nigeria.

West African Journal of Medicine
|May 30, 2021
PubMed

Insights

Abnormal cerebral blood flow velocities (CBFV) in children with sickle cell anaemia (SCA) indicate stroke risk. This Nigerian study found a significant proportion of SCA children require routine monitoring for stroke prevention.

Area of Science:

  • Neurology
  • Pediatrics
  • Hematology

Background:

  • Cerebral blood flow velocities (CBFV) abnormalities in sickle cell anaemia (SCA) predict stroke risk.
  • Transcranial Doppler Imaging (TCDI) ultrasonography is crucial for detecting these CBFV abnormalities.
  • Routine TCDI is a key strategy in managing children with SCA globally.

Purpose of the Study:

  • To investigate the pattern of CBFV in Nigerian children with SCA.
  • To identify the proportion of SCA children at risk of stroke using TCDI.
  • To establish stroke risk stratification based on modified STOP trial criteria.

Main Methods:

  • A cross-sectional study involved 130 children (aged 2-16 years) with SCA at National Hospital Abuja, Nigeria.
  • Systematic random sampling was used for participant recruitment.
  • CBFV in the middle cerebral artery (MCA) were measured via TCDI, with stroke risk categorized as normal (<155cm/sec), conditional (155-179cm/sec), and abnormal (>180cm/sec).

Main Results:

  • Out of 130 SCA children, 81.5% had normal CBFV, 11.5% conditional, and 6.9% abnormal (high risk).
  • The highest CBFV recorded were 272cm/sec in the right MCA and 262cm/sec in the right internal carotid artery (ICA).
  • Significant interhemispheric differences in CBFV were observed in the posterior cerebral artery (PCA) and ICA.

Conclusions:

  • A notable proportion of Nigerian children with SCA are identified as being at risk of stroke.
  • Routine monitoring of CBFV is essential for stroke risk assessment in pediatric SCA patients.
  • Early detection and intervention are critical for stroke prevention in SCA.
Abstract

Keywords:
Anterior Cerebral Artery (ACA)Cerebral ArteriesCerebral blood flow velocity (CBFV)Conventional Transcranial Doppler (cTCD)Internal Carotid Artery (ICA)Middle Cerebral Artery (MCA)Posterior Cerebral Artery(PCA)Sickle Cell Anaemia (SCA)Strokenscranial Doppler Imaging (TCDI)

More Related Videos

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound10:41

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound

Published on: June 3, 2021

3.8K
Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery04:01

Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery

Published on: August 9, 2024

1.2K

Related Concept Videos

Assessing Blood pressure using a doppler ultrasound01:19

Assessing Blood pressure using a doppler ultrasound

To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
1.9K
Ultrasonography01:17

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
6.9K
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
107