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Robin Sequence: Neonatal Mandibular Distraction.

Kerry A Morrison1, Marcus V Collares2, Roberto L Flores3

  • 1Hansjörg Wyss Department of Plastic Surgery, NYU Langone Medical Center, 222 East 41st Street, New York, NY, 10017, USA.

Clinics in Plastic Surgery
|May 30, 2021
PubMed
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Caregiver Experiences With Infant PLANA Therapy for Cleft Lip and/or Palate: A Cross-Sectional Survey Study.

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Does American Cleft Palate Craniofacial Association Cleft Team Accreditation Address Cleft Burden? A National Analysis.

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An Analysis of Predictors of Early Morbidity and Mortality in Infants with Robin Sequence.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
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Adverse Outcomes After Mandibular Distraction Osteogenesis in Robin Sequence.

The Journal of craniofacial surgery·2026
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Socioeconomic Disparities in the Integrated Plastic Surgery Match.

Plastic and reconstructive surgery·2026
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20-Year Outcomes and Revision Surgery Rates in a Large Cohort of Patients Undergoing Nasoalveolar Molding Therapy.

Plastic and reconstructive surgery·2026

Mandibular distraction osteogenesis (MDO) effectively treats severe airway obstruction in Pierre Robin sequence by correcting mandibular hypoplasia. MDO shows greater success than other methods for infants with this condition.

Area of Science:

  • Craniofacial Surgery
  • Pediatric Otolaryngology
  • Congenital Anomalies

Background:

  • Pierre Robin sequence presents with mandibular hypoplasia, glossoptosis, and airway obstruction.
  • Severe airway obstruction necessitates timely intervention to prevent morbidity and mortality.

Purpose of the Study:

  • To provide a comprehensive review of neonatal mandibular distraction osteogenesis (MDO) for Pierre Robin sequence.
  • To offer evidence-based treatment guidelines for MDO in affected infants.

Main Methods:

  • Review of current literature on MDO for Pierre Robin sequence.
  • Analysis of surgical outcomes from over 400 patient cases.
  • Comparison of MDO efficacy with alternative treatments like tongue-lip adhesion.
Keywords:
GlossoptosisMandibular distraction osteogenesisMandibular morphologyMicrognathiaNeonatePierre Robin sequencePolysomnographySleep study

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Main Results:

  • MDO is the primary intervention directly addressing the anatomical cause of airway obstruction in Pierre Robin sequence.
  • MDO demonstrates superior success rates in resolving airway obstruction compared to tongue-lip adhesion.
  • MDO is effective even in syndromic cases with associated anomalies.

Conclusions:

  • Mandibular distraction osteogenesis is a highly effective treatment for severe airway obstruction in Pierre Robin sequence.
  • Established guidelines based on extensive surgical experience can optimize MDO outcomes.
  • Early and appropriate MDO intervention is crucial for managing Pierre Robin sequence.