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PolyJet printed high aspect ratio three-dimensional bifurcating microfluidic flow distributor and its application in

Vipul Gupta1, Brett Paull1

  • 1Australian Centre for Research on Separation Sciences (ACROSS) and ARC Centre of Excellence for Electromaterials Science (ACES), School of Natural Sciences, University of Tasmania, Sandy Bay, Hobart, 7001, Tasmania, Australia.

Analytica Chimica Acta
|May 30, 2021
PubMed
Summary

A novel 3D printed microfluidic distributor achieves uniform fluid flow in low-flow and high-aspect ratio conditions. This technology enhances performance in applications like organs-on-a-chip and solid-phase extraction.

Keywords:
3D printedBifurcating distributorFlow distributorMicrofluidic distributorMulti-lumen columnSolid-phase extractor

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Area of Science:

  • Microfluidics
  • Additive Manufacturing
  • Chemical Engineering

Background:

  • Uniform fluid distribution in microfluidic systems is challenging, especially in 3D.
  • Existing 3D printed distributors often fail at low flow rates or with high aspect ratios.
  • Applications like organs-on-a-chip and chromatography require precise fluid handling.

Purpose of the Study:

  • To design and develop a 3D microfluidic distributor for uniform fluid distribution.
  • To ensure functionality at low flow rates and in high aspect ratio environments.
  • To demonstrate its application in a high-performance online solid-phase extractor.

Main Methods:

  • Utilized PolyJet 3D printing for fabricating the three-dimensional bifurcating microfluidic distributor.
  • Performed Computational Fluid Dynamics (CFD) simulations to analyze flow distribution.
  • Integrated the distributor into an online solid-phase extraction system.

Main Results:

  • Achieved low maldistribution factors of 2.29% and 1.72% at specified flow rates via CFD simulation.
  • Demonstrated low-dispersion flow divergence and convergence across 64 parallel channels.
  • Developed a solid-phase extractor with 88.8% extraction efficiency, outperforming 2D and single-channel designs.

Conclusions:

  • The 3D printed microfluidic distributor effectively addresses challenges in uniform fluid distribution.
  • The design is suitable for low flow rates and high aspect ratio applications.
  • This technology significantly improves performance in solid-phase extraction systems.