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Effects of Ivermectin in Patients With COVID-19: A Multicenter, Double-blind, Randomized, Controlled Clinical Trial

Leila Shahbaznejad1, Alireza Davoudi2, Gohar Eslami3

  • 1Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Clinical Therapeutics
|May 30, 2021
PubMed
Abstract

Insights

Ivermectin, an antiparasitic drug, improved COVID-19 symptoms like dyspnea and cough in a clinical trial. The drug was well-tolerated, showing potential benefits for coronavirus disease 2019 patients.

Area of Science:

  • Infectious Diseases
  • Pharmacology

Background:

  • The COVID-19 pandemic created an urgent need for effective treatments.
  • Ivermectin, a widely used antiparasitic, was investigated for its potential therapeutic effects.

Purpose of the Study:

  • To evaluate the efficacy of ivermectin in improving outcomes for patients with COVID-19.
  • To assess the impact of ivermectin on symptom duration and clinical improvement.

Main Methods:

  • A randomized, double-blind clinical trial was conducted with 69 COVID-19 patients.
  • The intervention group received ivermectin plus standard care; the control group received standard care only.
  • Outcomes measured included duration of hospital stay, fever, dyspnea, cough, and overall clinical improvement.

Main Results:

  • Ivermectin significantly reduced the duration of dyspnea (2.6 vs. 3.8 days) and cough (3.1 vs. 4.8 days).
  • Hospital stay was shorter in the ivermectin group (7.1 vs. 8.4 days).
  • The frequency of lymphopenia decreased in the ivermectin group (14.3% vs. control).

Conclusions:

  • A single dose of ivermectin was well-tolerated and improved key clinical features of COVID-19.
  • Further research with larger sample sizes and varied dosages is recommended to confirm ivermectin's clinical benefits.
Keywords:
COVID-19clinical trialcoughdyspneaivermectinlymphopenia

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