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[Genetic predisposition to mucocutaneous fungal infections]

B Baghad1, A A Bousfiha2, S Chiheb3

  • 1Service de dermatologie vénéréologie, CHU de Casablanca, Hassan II University of Casablanca, Maroc; Laboratoire d'immunologie clinique, inflammation et allergie, Faculté de médecine et de pharmacie de Casablanca, Hassan II University of Casablanca, Maroc.

La Revue De Medecine Interne
|May 30, 2021
PubMed

Insights

Genetic factors can cause fungal infections like candidiasis even without typical risk factors. This review explores genetic susceptibilities linked to mucocutaneous fungal diseases.

Area of Science:

  • Immunology
  • Medical Mycology
  • Human Genetics

Background:

  • Mucocutaneous fungal infections, including candidiasis and dermatophytosis, are prevalent clinical conditions.
  • While often associated with identifiable risk factors, these infections can manifest in individuals lacking such predispositions.
  • This suggests an underlying genetic component influencing susceptibility, potentially involving innate or adaptive immune system deficiencies.

Purpose of the Study:

  • To review and elucidate the genetic factors contributing to mucocutaneous fungal infections.
  • To specifically highlight genetic predispositions in cases of candidiasis and dermatophytosis.
  • To underscore the role of genetic susceptibility in unexplained fungal infections.

Main Methods:

  • Literature review of genetic studies and clinical case reports.
  • Analysis of genetic variations associated with immune deficiencies.
  • Synthesis of evidence linking specific genes to fungal infection susceptibility.

Main Results:

  • Identification of several genetic factors associated with increased risk of fungal infections.
  • Correlation between specific immune deficiencies and susceptibility to candidiasis and dermatophytosis.
  • Demonstration of genetic predisposition in patients without conventional risk factors.

Conclusions:

  • Genetic susceptibility plays a significant role in the pathogenesis of mucocutaneous fungal infections.
  • Understanding these genetic factors is crucial for diagnosing and managing unexplained fungal diseases.
  • Further research into the genetic basis of fungal immunity can inform novel therapeutic strategies.
Keywords:
CandidiasisCandidoseDematophytosisDermatophytiesDéficit immunitaire primitifFungal skin diseaseGenetic predispositionMycose cutanéePrimary immunodeficiencyPrédisposition génétique

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