Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-related changes in human skeletal muscle microstructure and architecture assessed by diffusion-tensor magnetic resonance imaging and their association with muscle strength.

Aging cell·2023
Same author

Severity of polycystic kidney disease revealed by multiparametric MRI.

Magnetic resonance in medicine·2023
Same author

Correction of errors in estimates of T<sub>1ρ</sub> at low spin-lock amplitudes in the presence of B<sub>0</sub> and B<sub>1</sub> inhomogeneities.

NMR in biomedicine·2023
Same author

R<sub>1ρ</sub> dispersion in white matter correlates with quantitative metrics of cognitive impairment.

NeuroImage. Clinical·2023
Same author

Multiparametric magnetic resonance imaging in diagnosis of long-term renal atrophy and fibrosis after ischemia reperfusion induced acute kidney injury in mice.

NMR in biomedicine·2022
Same author

Ankle-Brachial Index and Energy Production in People Without Peripheral Artery Disease: The BLSA.

Journal of the American Heart Association·2022
Same journal

Systematic comparison of MPRAGE and BRAVO T1-weighted MRI pulse sequences and brain morphometry in high-risk young adults.

Magnetic resonance imaging·2026
Same journal

Foot dynamic contrast-enhanced MRI for assessing microcirculatory changes after endovascular therapy in peripheral artery disease: A prospective pilot study.

Magnetic resonance imaging·2026
Same journal

Reconstruction of MRI from undersampled k-spaces of double-contrast volume acquisitions using deep neural networks.

Magnetic resonance imaging·2026
Same journal

Radiofrequency-induced heating safety of brain MRI scans at 7 T in the presence of a shoulder implant.

Magnetic resonance imaging·2026
Same journal

Incremental diagnostic value of microstructural time-dependent diffusion MRI in differentiating PCNSL from glioblastoma over conventional MRI.

Magnetic resonance imaging·2026
Same journal

Enhanced respiratory motion compensation in free-breathing dynamic contrast-enhanced MRI with GROG-facilitated bunch phase encoding and Golden angle radial sampling.

Magnetic resonance imaging·2026
See all related articles

Related Experiment Video

Updated: Nov 4, 2025

Real-Time, Two-Color Stimulated Raman Scattering Imaging of Mouse Brain for Tissue Diagnosis
10:57

Real-Time, Two-Color Stimulated Raman Scattering Imaging of Mouse Brain for Tissue Diagnosis

Published on: February 1, 2022

3.3K

Tissue characterization using R1rho dispersion imaging at low locking fields.

Fatemeh Adelnia1, Zhongliang Zu2, John T Spear3

  • 1Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.

Magnetic Resonance Imaging
|May 30, 2021
PubMed
Summary
This summary is machine-generated.

Spin-locking relaxation rate (R1ρ) variations reveal molecular dynamics like diffusion and exchange. R1ρ dispersion imaging in the brain and muscle offers new clinical applications by analyzing tissue microstructures.

More Related Videos

Highly-Multiplexed Tissue Imaging with Raman Dyes
07:18

Highly-Multiplexed Tissue Imaging with Raman Dyes

Published on: April 21, 2022

3.1K
Practical Aspects of Sample Preparation and Setup of 1H R1&#961; Relaxation Dispersion Experiments of RNA
08:17

Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA

Published on: July 9, 2021

4.9K

Related Experiment Videos

Last Updated: Nov 4, 2025

Real-Time, Two-Color Stimulated Raman Scattering Imaging of Mouse Brain for Tissue Diagnosis
10:57

Real-Time, Two-Color Stimulated Raman Scattering Imaging of Mouse Brain for Tissue Diagnosis

Published on: February 1, 2022

3.3K
Highly-Multiplexed Tissue Imaging with Raman Dyes
07:18

Highly-Multiplexed Tissue Imaging with Raman Dyes

Published on: April 21, 2022

3.1K
Practical Aspects of Sample Preparation and Setup of 1H R1&#961; Relaxation Dispersion Experiments of RNA
08:17

Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA

Published on: July 9, 2021

4.9K

Area of Science:

  • Magnetic Resonance Imaging
  • Biophysics
  • Medical Physics

Background:

  • Spin-locking relaxation rates (R1ρ) quantify dynamic processes like molecular motion, chemical exchange, and diffusion.
  • R1ρ variations are sensitive to intrinsic magnetic field gradients, particularly in biological tissues due to microvasculature.

Purpose of the Study:

  • To review the theoretical and experimental basis for interpreting R1ρ dispersion from magnetic susceptibility variations.
  • To present novel empirical results of R1ρ dispersion imaging in human brain and skeletal muscle.
  • To identify potential clinical applications of R1ρ dispersion imaging.

Main Methods:

  • Measurements of R1ρ variations with varying locking field amplitudes.
  • Analysis of R1ρ dispersion, distinguishing between diffusion and exchange effects.
  • Application of R1ρ dispersion imaging at low locking field amplitudes.

Main Results:

  • R1ρ dispersion is influenced by water diffusion in intrinsic field gradients at low locking fields (≤ 200 Hz).
  • Exchange processes dominate R1ρ at higher locking fields.
  • Simulations and experiments confirm the independent action of exchange and diffusion effects.
  • First empirical results of R1ρ dispersion imaging in human brain and skeletal muscle are presented.

Conclusions:

  • R1ρ dispersion analysis provides quantitative insights into tissue microstructural properties like capillary density and geometry.
  • R1ρ dispersion imaging holds promise for clinical applications, particularly in studying tissue characteristics.