Related Experiment Video
Updated: Nov 4, 2025
Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images
Published on: January 7, 2019
Quantitative comparison of subcortical and ventricular volumetry derived from MPRAGE and MP2RAGE images using
Juli Alonso1,2,3, Deborah Pareto4,5,6, Manel Alberich4,5
1Neuroradiology Section, Department of Radiology (Institut de Diagnòstic per la Imatge), Vall d'Hebron Hospital Universitari, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain. juli.alonso.idi@gencat.cat.
Objective:
In brain volume assessment with MR imaging, it is of interest to know the effects of the pulse sequence and software used, to determine whether they provide equivalent data. The aim of this study was to compare cross-sectional volumes of subcortical and ventricular structures and their repeatability derived from MP2RAGE and MPRAGE images using MorphoBox, and FIRST or ALVIN.
Materials And Methods:
MPRAGE and MP2RAGE T1-weighted images were obtained from 24 healthy volunteers. Back-to-back scans were performed in 12 of them. Volumes, coefficients of variation, concordance, and correlations were determined.
Results:
Significant differences were found for volumes derived from MorphoBox and FIRST. Ventricular volumes determined by MorphoBox and ALVIN were similar. Differences between volumes obtained using MPRAGE and MP2RAGE were significant for a few regions. Coefficients of variation, ranged from 0.2 to 9.1%, showed a significant inverse correlation with the mean volume. There was a correlation between volume measures, but agreement was rated as poor for most regions.
Conclusion:
MP2RAGE sequences and MorphoBox are valid options for assessing subcortical and ventricular volumes, in the same way as MPRAGE and FIRST or ALVIN, accepted tools for clinical research. However, caution is needed when comparing volumes obtained with different tools.
