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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Imaging Studies III: Computed Tomography01:27

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Imaging Biological Samples with Optical Microscopy01:18

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Imaging Studies I: CT and MRI01:14

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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
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Imaging Studies for Cardiovascular System V: CT01:28

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Total Internal Reflection Fluorescence Microscopy01:05

Total Internal Reflection Fluorescence Microscopy

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Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
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Updated: Nov 4, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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Optical Coherence Tomography for Ophthalmology Imaging.

Jia Qin1, Lin An1

  • 1Innovation and Entrepreneurship Teams Project of Guangdong Pearl River Talents Program, Guangdong Weiren Meditech Co., Ltd, Foshan, Guangdong, People's Republic of China.

Advances in Experimental Medicine and Biology
|May 30, 2021
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) advancements, including time domain (TD-OCT), frequency domain (FD-OCT), and OCT angiography (OCTA), enable noninvasive, high-resolution imaging of the human retina for diagnosing eye diseases.

Keywords:
Clinical applicationHuman eyeImagingOCTOCTA

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Area of Science:

  • Ophthalmology
  • Biomedical Imaging
  • Optical Engineering

Background:

  • Optical coherence tomography (OCT) provides noninvasive, micrometer-scale resolution imaging of biological tissues.
  • OCT has become a standard diagnostic tool for various eye diseases.
  • Significant advancements have been made in OCT techniques over the last 30 years.

Purpose of the Study:

  • To illustrate the key developmental stages of OCT technology.
  • To highlight the clinical applications and progress of different OCT techniques.
  • To discuss the future potential of OCT in ophthalmology.

Main Methods:

  • Review of time domain OCT (TD-OCT) development and commercialization.
  • Explanation of frequency domain OCT (FD-OCT) principles and improvements over TD-OCT.
  • Introduction to optical coherence tomography angiography (OCTA) for retinal vasculature imaging.

Main Results:

  • TD-OCT enables in vivo 2D cross-sectional imaging of the human retina.
  • FD-OCT offers enhanced sensitivity and high imaging speeds (kHz range).
  • OCTA visualizes in vivo retinal microvasculature, aiding diagnosis of structural and vascular abnormalities.

Conclusions:

  • OCT has evolved through distinct stages: TD-OCT, FD-OCT, and OCTA.
  • Each OCT technique has significantly improved in vivo human eye imaging for clinical applications.
  • Continued advancements in speed, contrast, and resolution will further enhance OCT's clinical utility.