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Updated: Nov 4, 2025

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
Published on: May 7, 2019
Cytotoxic T Lymphocytes (CTLs) and Kidney Transplantation: An Overview
Federica Rascio1, Paola Pontrelli2, Giuseppe Grandaliano3,4
1Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, Faculty of Medicine, University of Foggia, Foggia, Italy. federica.rascio@gmail.com.
Abstract:
Involvement of T lymphocytes in kidney transplantation is a well-developed topic; however, most of the scientific interest focused on the different type of CD4+ lymphocyte subpopulations. Few authors, instead, investigated the role of CD8+ T cells in renal transplantation and how deleterious they can be to long-term allograft survival. Recently, there has been a renewed interest in the CD8+ T cells involvement in the transplantation field with the aim to investigate the immunological mechanisms underlying the infiltration of CD8+ T cells and their biological functions in human kidney allografts. The purpose of the present review is to highlight the role of allo-reactive cytotoxic T lymphocytes (CTLs) CD8+ subset in allograft kidney recipients and their related clinical complications.
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