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Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
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Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
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Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Irreversible Bladder Remodeling Induced by Fibrosis.

Su Jin Kim1, Jayoung Kim2,3,4,5, Yong Gil Na6

  • 1Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.

International Neurourology Journal
|May 31, 2021
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Underactive bladder and impaired bladder compliance stem from bladder fibrosis, a condition linked to extracellular matrix remodeling. More research is needed to understand bladder fibrosis mechanisms and find effective treatments.

Keywords:
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Area of Science:

  • Neurourology
  • Urology
  • Fibrosis Research

Background:

  • Underactive bladder and impaired bladder compliance are irreversible conditions.
  • Bladder fibrosis, characterized by extracellular matrix remodeling, underlies these functional impairments.
  • Current understanding of bladder fibrosis in neurourology is limited.

Purpose of the Study:

  • To highlight the significance of bladder fibrosis in urological conditions.
  • To underscore the need for further investigation into the mechanisms of bladder fibrosis.
  • To emphasize the search for effective therapeutic strategies for bladder fibrosis.

Main Methods:

  • Review of existing literature on bladder fibrosis and extracellular matrix remodeling.
  • Analysis of risk factors and conditions contributing to bladder fibrosis.
  • Identification of knowledge gaps in the field of neurourology concerning bladder fibrosis.

Main Results:

  • Bladder fibrosis is a key factor in underactive bladder and impaired compliance.
  • Extracellular matrix remodeling is a central mechanism in bladder fibrosis development.
  • Limited research exists on the neurourological aspects of bladder fibrosis.

Conclusions:

  • Bladder fibrosis presents significant challenges in neurourology.
  • Elucidating the mechanisms of bladder fibrosis is crucial for therapeutic development.
  • Further studies are essential to identify effective treatments for bladder fibrosis-associated conditions.