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Related Experiment Video

Updated: Nov 4, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
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[Knowledge graph characteristics of sepsis research based on scientometric study].

Tiantian Fan1, Shengwen Song2, Hui Li2

  • 1College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
|May 31, 2021
PubMed
Summary

This study maps sepsis research from 1985-2019, revealing a focus on basic science and organ dysfunction. Future trends point towards childhood sepsis, organ injury mechanisms, and integrated treatment approaches for multiple organ dysfunction syndrome (MODS).

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Area of Science:

  • * Medical Informatics
  • * Bibliometrics
  • * Sepsis Research

Background:

  • * Sepsis is a complex condition with significant research output.
  • * Understanding the knowledge landscape of sepsis research is crucial for guiding future scientific inquiry and clinical practice.
  • * A comprehensive overview of sepsis research trends, from historical evolution to emerging hotspots, is needed.

Purpose of the Study:

  • * To construct a comprehensive knowledge system of sepsis research, encompassing historical outputs, current hotspots, and future trends.
  • * To aid researchers and clinicians in identifying key research directions and clinical focuses for sepsis treatment.
  • * To provide a data-driven perspective on the evolution and trajectory of sepsis studies.

Main Methods:

  • * Bibliometric analysis of 8,189 sepsis-related publications from 1985 to 2019, sourced from the Web of Science database.
  • * Utilization of CiteSpace and VOSviewer software for data mining, information processing, and knowledge mapping.
  • * Analysis of historical evolution and prediction of development trends through visualization techniques.

Main Results:

  • * Publication volume increased annually, peaking in 2019 with 1,276 papers.
  • * Research predominantly focused on epidemiological studies and animal experiments, with key areas including septic rat models, necrotizing enterocolitis, sepsis-associated encephalopathy, acute kidney injury (AKI), gut-derived sepsis, and inflammatory mediators.
  • * Emerging trends highlight endotoxin, inflammation, immunity, multiple organ dysfunction syndrome (MODS), and sepsis management (diagnosis, chemotherapy).

Conclusions:

  • * Current sepsis research emphasizes basic science, epidemiology, inflammatory responses, immune function, and organ dysfunction.
  • * Future research is predicted to concentrate on childhood sepsis, organ injury mechanisms, and interventions for MODS.
  • * Integrated management strategies, potentially combining traditional Chinese medicine and Western medicine, are identified as a future research direction.