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Advances in Systemic Therapy for Gastric Cancer
Andrew Hsu1, Alexander G Raufi1
1The Warren Alpert Medical School of Brown University, Lifespan Cancer Institute, Rhode Island Hospital/The Miriam Hospital, 164 Summit Avenue, Fain Building, Third Floor, Providence, RI 02906, USA.
Gastric cancer is a significant global health issue. This review covers approved and investigational systemic treatments for early-stage and metastatic gastric cancer, focusing on chemotherapy and radiotherapy combinations.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Gastric cancer poses a substantial global health burden.
- Early-stage diagnosis allows for potentially curative surgical resection.
- Adjuvant or neoadjuvant therapies, including chemotherapy and radiotherapy, improve surgical outcomes.
Purpose of the Study:
- To review current approved systemic treatment options for gastric cancer.
- To discuss promising investigational therapies for gastric cancer.
Main Methods:
- Literature review of approved systemic treatments.
- Summary of clinical trial data for investigational therapies.
Main Results:
- Combination chemotherapy (2- or 3-drug regimens) is standard for metastatic disease.
- Combined modality treatments enhance outcomes for resectable gastric cancer.
- Several novel agents are under investigation for gastric cancer.
Conclusions:
- Systemic therapy plays a crucial role in managing gastric cancer at all stages.
- Ongoing research is expanding the therapeutic landscape for gastric cancer patients.
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