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Epithelial membrane antigen expression in ependymomas.

F F Cruz-Sanchez¹, M L Rossi, M M Esiri

¹Department of Neuropathology, Radcliffe Infirmary, Oxford.

Neuropathology and Applied Neurobiology

|May 1, 1988

Summary

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Epithelial membrane antigen (EMA) staining differentiates benign from malignant ependymomas, while glial fibrillary acidic protein (GFAP) is present in all tumor grades. This aids in histological assessment.

Area of Science:

Neuroscience
Oncology
Immunohistochemistry

Background:

Ependymomas are tumors arising from ependymal cells.
Distinguishing between low-grade (benign) and high-grade (malignant) ependymomas is crucial for prognosis and treatment.
Immunohistochemical markers can aid in tumor classification.

Purpose of the Study:

To investigate the differential expression of epithelial membrane antigen (EMA) and glial fibrillary acidic protein (GFAP) in ependymomas.
To assess the utility of EMA and GFAP in distinguishing benign from malignant ependymomas.
To explore potential implications for ependymoma cytogenesis and histological grading.

Main Methods:

Studied 27 ependymomas (18 low-grade, 9 high-grade).
Utilized monoclonal antibody to epithelial membrane antigen (E29).

Related Experiment Videos

Employed antiserum to glial fibrillary acidic protein (GFAP).

Main Results:

Epithelial membrane antigen (E29) antibody reacted with low-grade ependymomas but not high-grade ones.
EMA staining was observed on the cell surface, particularly facing rosette lumina.
Glial fibrillary acidic protein (GFAP) reactivity was present in all ependymomas, with perivascular accentuation in high-grade tumors.

Conclusions:

EMA expression is a potential marker for differentiating benign from malignant ependymomas.
GFAP is expressed across all ependymoma grades, suggesting glial lineage.
These findings may inform ependymoma cytogenesis and improve histological assessment.