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Published on: August 16, 2021
Isoniazid-induced Immune Thrombocytopenia
Gaku Kuwabara1,2, Kumiyo Tazoe3, Waki Imoto1,2
1Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan.
Isoniazid, an uncommon cause of drug-induced thrombocytopenia, can lead to immune-mediated platelet destruction during tuberculosis treatment. Discontinuation of isoniazid led to normalized platelet counts in a patient, highlighting its potential role.
Area of Science:
- Immunology
- Hematology
- Pharmacology
Background:
- Drug-induced thrombocytopenia (DIT) is a serious adverse effect often requiring treatment cessation.
- Tuberculosis (TB) treatment involves multiple drugs, complicating the identification of causative agents for DIT.
- Rifampicin is a common cause of DIT, but other anti-TB drugs like isoniazid can also induce this condition.
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